[HTML][HTML] Sea anemone toxins: A structural overview

B Madio, GF King, EAB Undheim - Marine drugs, 2019 - mdpi.com
Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …

Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

[HTML][HTML] Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux

S Cabezas, S Ho, U Ros, ME Lanio, C Alvarez… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Pore-forming toxins (PFTs) form holes in membranes causing one of the most catastrophic
damages to a target cell. Target organisms have evolved a regulated response against PFTs …

Pore-forming toxins in Cnidaria

M Podobnik, G Anderluh - Seminars in Cell & Developmental Biology, 2017 - Elsevier
The ancient phylum of Cnidaria contains many aquatic species with peculiar lifestyle. In
order to survive, these organisms have evolved attack and defense mechanisms that are …

[HTML][HTML] Magnificamide, a β-Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian α-Amylases

O Sintsova, I Gladkikh, A Kalinovskii, E Zelepuga… - Marine Drugs, 2019 - mdpi.com
Sea anemones' venom is rich in peptides acting on different biological targets, mainly on
cytoplasmic membranes and ion channels. These animals are also a source of pancreatic α …

The sea anemone neurotoxins modulating sodium channels: an insight at structure and functional activity after four decades of investigation

MM Monastyrnaya, RS Kalina, EP Kozlovskaya - Toxins, 2022 - mdpi.com
Many human cardiovascular and neurological disorders (such as ischemia, epileptic
seizures, traumatic brain injury, neuropathic pain, etc.) are associated with the abnormal …

[HTML][HTML] Evolution of the cytolytic pore-forming proteins (Actinoporins) in sea anemones

J Macrander, M Daly - Toxins, 2016 - mdpi.com
Sea anemones (Cnidaria, Anthozoa, and Actiniaria) use toxic peptides to incapacitate and
immobilize prey and to deter potential predators. Their toxin arsenal is complex, targeting a …

[HTML][HTML] The chemical armament of reef-building corals: inter-and intra-specific variation and the identification of an unusual actinoporin in Stylophora pistilata

H Ben-Ari, M Paz, D Sher - Scientific reports, 2018 - nature.com
Corals, like other cnidarians, are venomous animals that rely on stinging cells (nematocytes)
and their toxins to catch prey and defend themselves against predators. However, little is …

[HTML][HTML] New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa

I Gladkikh, M Monastyrnaya, E Zelepuga, O Sintsova… - Marine Drugs, 2015 - mdpi.com
Sea anemones are a rich source of Kunitz-type polypeptides that possess not only protease
inhibitor activity, but also Kv channels toxicity, analgesic, antihistamine, and anti …

Transcriptomic and proteomic analyses reveal the first occurrence of diverse toxin groups in Millepora alcicornis

VH Hérnández-Elizárraga, JE Vega-Tamayo… - Journal of …, 2023 - Elsevier
Millepora alcicornis is a reef-forming cnidarian widely distributed in the Mexican Caribbean.
Millepora species or “fire corals" inflict a painful stinging reaction in humans when touched …