More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Neutrophils—from bone marrow to first-line defense of the innate immune system

RF Kraus, MA Gruber - Frontiers in immunology, 2021 - frontiersin.org
Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

[КНИГА][B] Biochemistry of collagens, laminins and elastin: structure, function and biomarkers

M Karsdal - 2023 - books.google.com
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third
Edition provides current data on key structural proteins (collagens, laminins, and elastin) …

[HTML][HTML] The basement membrane in the cross-roads between the lung and kidney

K Jandl, AC Mutgan, K Eller, L Schaefer… - Matrix Biology, 2022 - Elsevier
The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …

The role of DNA methylation in personalized medicine for immune-related diseases

MK Gupta, H Peng, Y Li, CJ Xu - Pharmacology & Therapeutics, 2023 - Elsevier
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases

MM Joglekar, M Nizamoglu, YW Fan… - Frontiers in …, 2022 - frontiersin.org
Environmental insults including respiratory infections, in combination with genetic
predisposition, may lead to lung diseases such as chronic obstructive pulmonary disease …

[HTML][HTML] Basement membranes in obstructive pulmonary diseases

BGJ Dekkers, SI Saad, LJ van Spelde, JK Burgess - Matrix biology plus, 2021 - Elsevier
Increased and changed deposition of extracellular matrix proteins is a key feature of airway
wall remodeling in obstructive pulmonary diseases, including asthma and chronic …

The signalling and functional role of the extracellular matrix in the development of liver fibrosis

IF Villesen, SJ Daniels, DJ Leeming… - Alimentary …, 2020 - Wiley Online Library
Background Patients with liver fibrosis show a large heterogeneity, and for that reason
effective treatments are still lacking. Emerging data suggest that there is more to fibrosis than …

Different phenotypes in asthma: clinical findings and experimental animal models

LO Lourenco, AM Ribeiro, FDTQS Lopes… - Clinical Reviews in …, 2022 - Springer
Asthma is a respiratory allergic disease presenting a high prevalence worldwide, and it is
responsible for several complications throughout life, including death. Fortunately, asthma is …

The multi-faceted extracellular matrix: Unlocking its secrets for understanding the perpetuation of lung fibrosis

M Nizamoglu, JK Burgess - Current Tissue Microenvironment Reports, 2021 - Springer
Abstract Purpose of Review Lung fibrosis is currently thought to stem from an aberrant
wound healing response after recurring (micro) injuries in the lung epithelium, together with …