The use of Cre recombinase to carry out conditional mutagenesis of transgenes and insert
DNA cassettes into eukaryotic chromosomes is widespread (1–9). Indeed, a PubMed search …

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …

Abstract Background The CRISPR/Cas9 system is increasingly used for gene inactivation in
mouse zygotes, but homology-directed mutagenesis and use of inbred embryos are less …

Cell‐penetrating peptides (CPPs) are capable of introducing a wide range of cargoes into
living cells. Descriptions of the internalization process vary from energy‐independent cell …

The delivery of proteins instead of DNA into plant cells allows for a transient presence of the
protein or enzyme that can be useful for biochemical analysis or genome modifications. This …

The derivation of human embryonic stem (hES) cells has opened new avenues for studies
on human development and provided a potential source of cells for replacement therapy. To …

Directed differentiation of human embryonic stem cells (hESCs) may yield models to study
organogenesis, produce cells and tissues for therapies, and identify clinically relevant …

Oculodentodigital dysplasia (ODDD) is a dominant negatively inherited disorder with
variable but characteristic anomalies of the fingers and toes, eyes, face and teeth, which are …

There is increasing evidence that dendritic cell (DC) immunogenicity is not only positively
regulated by ligands of pattern recognition receptors, but also negatively by signals that …

Intracellular delivery of biomolecules is a prerequisite for genetic techniques such as
recombinant engineering and genome editing. Realizing the full potential of this technology …