Essential hypertension: part I: definition and etiology
OA Carretero, S Oparil - Circulation, 2000 - Am Heart Assoc
Although it has frequently been indicated that the causes of essential hypertension are not
known, this is only partially true because we have little information on genetic variations or …
known, this is only partially true because we have little information on genetic variations or …
Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases
P Meneton, X Jeunemaitre… - Physiological …, 2005 - journals.physiology.org
Epidemiological, migration, intervention, and genetic studies in humans and animals
provide very strong evidence of a causal link between high salt intake and high blood …
provide very strong evidence of a causal link between high salt intake and high blood …
The hypertension pandemic: an evolutionary perspective
Hypertension affects over 1.2 billion individuals worldwide and has become the most critical
and expensive public health problem. Hypertension is a multifactorial disease involving …
and expensive public health problem. Hypertension is a multifactorial disease involving …
Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited
Transcription and translation require a high concentration of potassium across the entire tree
of life. The conservation of a high intracellular potassium was an absolute requirement for …
of life. The conservation of a high intracellular potassium was an absolute requirement for …
Single nucleotide polymorphisms and the future of genetic epidemiology
NJ Schork, D Fallin, JS Lanchbury - Clinical genetics, 2000 - Wiley Online Library
In this review, we consider the motivation behind contemporary Single Nucleotide
Polymorphism (SNP) initiatives. Many of these initiatives are projected to involve large …
Polymorphism (SNP) initiatives. Many of these initiatives are projected to involve large …
New strategies for identifying gene-gene interactions in hypertension
Essential hypertension is a common disease that has complex multifactorial etiology. For
this reason, it is not surprising that studies of the effects of single genes on hypertension …
this reason, it is not surprising that studies of the effects of single genes on hypertension …
Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis
AA Sethi, BG Nordestgaard… - … , and vascular biology, 2003 - Am Heart Assoc
Objective—The aim of this study was to investigate whether the M235T polymorphism in the
angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic …
angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic …
The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension
S Engeli, AM Sharma - Journal of molecular medicine, 2001 - Springer
Excessive accumulation of adipose tissue is associated with profound alterations in the
cardiovascular system, including an increase in systemic blood pressure. It now appears …
cardiovascular system, including an increase in systemic blood pressure. It now appears …
Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches
SE Humphries, L Morgan - The Lancet Neurology, 2004 - thelancet.com
Ischaemic stroke is the most common form of stroke and is caused by athero-sclerosis in
most patients. Several genetic determinants contribute to stroke risk. Of these, carotid intimal …
most patients. Several genetic determinants contribute to stroke risk. Of these, carotid intimal …
The role of angiotensin II in cognition and behaviour
PR Gard - European journal of pharmacology, 2002 - Elsevier
Polymorphisms of the renin–angiotensin system are associated with cardiovascular
disorders, possibly as a consequence of increased brain angiotensin II activity. Within the …
disorders, possibly as a consequence of increased brain angiotensin II activity. Within the …