While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Reducing body weight to improve metabolic health and related comorbidities is a primary
goal in treating obesity,. However, maintaining weight loss is a considerable challenge …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

Adipose tissue development is poorly understood. Here we use a lineage-tracing strategy
optimal for adipocytes to provide evidence that Myf5 precursors are not the exclusive source …

Insulin signalling is uniquely required for storing energy as fat in humans. While de novo
synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary …

Conditional gene targeting has been extensively used for in vivo analysis of gene function in
adipocyte cell biology but often with debate over the tissue specificity and the efficacy of …