Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities

I Russo, NG Frangogiannis - Journal of molecular and cellular cardiology, 2016 - Elsevier
Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …

Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities

I Tuleta, NG Frangogiannis - Advanced drug delivery reviews, 2021 - Elsevier
In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights

LJ Bohne, D Johnson, RA Rose, SB Wilton… - Frontiers in …, 2019 - frontiersin.org
A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk
factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age …

Tetrahydrocurcumin ameliorates diabetic cardiomyopathy by attenuating high glucose‐induced oxidative stress and fibrosis via activating the SIRT1 pathway

K Li, M Zhai, L Jiang, F Song, B Zhang… - Oxidative medicine …, 2019 - Wiley Online Library
Hyperglycemia‐induced oxidative stress and fibrosis play a crucial role in the development
of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite …

Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy

Y Cheng, Y Wang, R Yin, Y Xu, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can
eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis …

Metabolic control of collagen synthesis

J Guillard, S Schwörer - Matrix Biology, 2024 - Elsevier
The extracellular matrix (ECM) is present in all tissues and crucial in maintaining normal
tissue homeostasis and function. Defects in ECM synthesis and remodeling can lead to …

[HTML][HTML] Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease

HJ Jansen, LJ Bohne, AM Gillis, RA Rose - Heart Rhythm O2, 2020 - Elsevier
Atrial fibrillation (AF) is prevalent in common conditions and acquired forms of heart disease,
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …

Diabetes mellitus and atrial fibrillation-from pathophysiology to treatment

M Leopoulou, P Theofilis, A Kordalis… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is a leading risk factor for cardiovascular complications
around the globe and one of the most common medical conditions. Atrial fibrillation (AF) is …

Myocyte-derived Hsp90 modulates collagen upregulation via biphasic activation of STAT-3 in fibroblasts during cardiac hypertrophy

R Datta, T Bansal, S Rana, K Datta… - … and cellular biology, 2017 - Taylor & Francis
Signal transducer and activator of transcription 3 (STAT-3)-mediated signaling in relation to
upregulated collagen expression in fibroblasts during cardiac hypertrophy is well defined …

Glucose transporters in cardiovascular system in health and disease

L Bertrand, J Auquier, E Renguet, M Angé… - … -European Journal of …, 2020 - Springer
Glucose transporters are essential for the heart to sustain its function. Due to its nature as a
high energy-consuming organ, the heart needs to catabolize a huge quantity of metabolic …