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Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities
Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities
In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …
The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights
A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk
factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age …
factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age …
Tetrahydrocurcumin ameliorates diabetic cardiomyopathy by attenuating high glucose‐induced oxidative stress and fibrosis via activating the SIRT1 pathway
K Li, M Zhai, L Jiang, F Song, B Zhang… - Oxidative medicine …, 2019 - Wiley Online Library
Hyperglycemia‐induced oxidative stress and fibrosis play a crucial role in the development
of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite …
of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite …
Central role of cardiac fibroblasts in myocardial fibrosis of diabetic cardiomyopathy
Y Cheng, Y Wang, R Yin, Y Xu, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes, can
eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis …
eventually develop into heart failure and affect the prognosis of patients. Myocardial fibrosis …
Metabolic control of collagen synthesis
The extracellular matrix (ECM) is present in all tissues and crucial in maintaining normal
tissue homeostasis and function. Defects in ECM synthesis and remodeling can lead to …
tissue homeostasis and function. Defects in ECM synthesis and remodeling can lead to …
[HTML][HTML] Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease
Atrial fibrillation (AF) is prevalent in common conditions and acquired forms of heart disease,
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …
Diabetes mellitus and atrial fibrillation-from pathophysiology to treatment
M Leopoulou, P Theofilis, A Kordalis… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is a leading risk factor for cardiovascular complications
around the globe and one of the most common medical conditions. Atrial fibrillation (AF) is …
around the globe and one of the most common medical conditions. Atrial fibrillation (AF) is …
Myocyte-derived Hsp90 modulates collagen upregulation via biphasic activation of STAT-3 in fibroblasts during cardiac hypertrophy
Signal transducer and activator of transcription 3 (STAT-3)-mediated signaling in relation to
upregulated collagen expression in fibroblasts during cardiac hypertrophy is well defined …
upregulated collagen expression in fibroblasts during cardiac hypertrophy is well defined …
Glucose transporters in cardiovascular system in health and disease
L Bertrand, J Auquier, E Renguet, M Angé… - … -European Journal of …, 2020 - Springer
Glucose transporters are essential for the heart to sustain its function. Due to its nature as a
high energy-consuming organ, the heart needs to catabolize a huge quantity of metabolic …
high energy-consuming organ, the heart needs to catabolize a huge quantity of metabolic …