Cytostatic effect of the hypothalamic cytokine PRP-1 is mediated by mTOR and cMyc inhibition in high grade chondrosarcoma
K Galoian, TH Temple, A Galoyan - Neurochemical research, 2011 - Springer
This study aimed to further elucidate the molecular mechanisms of antiproliferative action of
proline rich polypeptide 1 (PRP-1) cytokine, produced by neurosecretory cells of the …
proline rich polypeptide 1 (PRP-1) cytokine, produced by neurosecretory cells of the …
Cytostatic effect of novel mTOR inhibitor, PRP-1 (galarmin) in MDA 231 (ER−) breast carcinoma cell line. PRP-1 inhibits mesenchymal tumors
KA Galoian, TH Temple, A Galoyan - Tumor Biology, 2011 - Springer
Activation of the PI3K–Akt–mTOR pathway is implicated both in the establishment of tumors
and as well as a target for therapy in many types of solid malignancy, its blockade …
and as well as a target for therapy in many types of solid malignancy, its blockade …
Proline-rich polypeptide-1 protects the cells in vitro from genotoxic effects of mitomycin C
RM Aroutiounian, GG Hovhannisyan… - Neurochemical …, 2010 - Springer
A new proline-rich polypeptide (PRP-1) has been earlier shown to possess a broad
spectrum of biological activities and seems to be a potential medicine. The potential …
spectrum of biological activities and seems to be a potential medicine. The potential …