Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …

Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …

Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …

To maximize the impact of precision medicine approaches, it is critical to identify genetic
variants underlying disease and to accurately quantify their functional effects. A gene …

Genome sequencing studies have identified millions of somatic variants in cancer, but it
remains challenging to predict the phenotypic impact of most. Experimental approaches to …

The protein structure field is experiencing a revolution. From the increased throughput of
techniques to determine experimental structures, to developments such as cryo-EM that …

Summary Interferon-γ (IFN-γ) signaling mediates host responses to infection, inflammation
and anti-tumor immunity. Mutations in the IFN-γ signaling pathway cause immunological …

The future of clinical diagnosis and treatment of hematologic diseases will inevitably involve
the integration of artificial intelligence (AI)-based systems into routine practice to support the …