Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …

Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature
organs, termed organoids, that replicate the key structural and functional characteristics of …

One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Abstract In 2013, the “biofabrication window” was introduced to reflect the processing
challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …