Lysosomal membrane permeabilization in cell death

P Boya, G Kroemer - Oncogene, 2008 - nature.com
Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …

Targeting proteases: successes, failures and future prospects

B Turk - Nature reviews Drug discovery, 2006 - nature.com
Until fairly recently, proteases were considered primarily to be protein-degrading enzymes.
However, this view has dramatically changed and proteases are now seen as extremely …

Serpin structure, mechanism, and function

PGW Gettins - Chemical reviews, 2002 - ACS Publications
Serpins are a superfamily of proteins, whose membership is based on the presence of a
single common core domain consisting of three β-sheets and 8-9 R-helices, and with a set of …

Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases

B Korkmaz, MS Horwitz, DE Jenne, F Gauthier… - Pharmacological …, 2010 - Elsevier
Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract

MA Schell, M Karmirantzou, B Snel… - Proceedings of the …, 2002 - National Acad Sciences
Bifidobacteria are Gram-positive prokaryotes that naturally colonize the human
gastrointestinal tract (GIT) and vagina. Although not numerically dominant in the complex …

Phenoloxidase: a key component of the insect immune system

I González‐Santoyo… - Entomologia …, 2012 - Wiley Online Library
The innate immune system in insects is composed of a large variety of specific and non‐
specific responses that are activated in response to the presence of foreign agents. One …

Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity

K Hida, J Wada, J Eguchi, H Zhang… - Proceedings of the …, 2005 - National Acad Sciences
There is a rapid global rise in obesity, and the link between obesity and diabetes remains
somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue …

Cell-mediated immunity in arthropods: hematopoiesis, coagulation, melanization and opsonization

P Jiravanichpaisal, BL Lee, K Söderhäll - Immunobiology, 2006 - Elsevier
Cell-mediated immunity in arthropods: Hematopoiesis, coagulation, melanization and
opsonization - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

An overview of the serpin superfamily

RHP Law, Q Zhang, S McGowan, AM Buckle… - Genome biology, 2006 - Springer
Serpins are a broadly distributed family of protease inhibitors that use a conformational
change to inhibit target enzymes. They are central in controlling many important proteolytic …

Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism

R Garcia-Martin, BB Brandao, T Thomou, E Altindis… - Cell reports, 2022 - cell.com
Exosomes/small extracellular vesicles (sEVs) can serve as multifactorial mediators of cell-to-
cell communication through their miRNA and protein cargo. Quantitative proteomic analysis …