Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Oxidative stress and associated reactive oxygen species can modify lipids, proteins,
carbohydrates, and nucleic acids, and induce the mitochondrial permeability transition …

Pericytes and mesenchymal stem cells (MSCs) are ontogenically related, and in fact, no
significant phenotypic differences could be observed by flow cytometry. Transcriptome …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

Cardiac fibroblasts (CF) are well-established as key regulators of extracellular matrix (ECM)
turnover in the context of myocardial remodelling and fibrosis. Recently, this cell type has …