Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment

H Rodriguez, JC Zenklusen, LM Staudt, JH Doroshow… - Cell, 2021 - cell.com
When it comes to precision oncology, proteogenomics may provide better prospects to the
clinical characterization of tumors, help make a more accurate diagnosis of cancer, and …

Integrated analysis of transcriptomic and proteomic data

S Haider, R Pal - Current genomics, 2013 - ingentaconnect.com
Until recently, understanding the regulatory behavior of cells has been pursued through
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …

Bayesian consensus clustering

EF Lock, DB Dunson - Bioinformatics, 2013 - academic.oup.com
Motivation: In biomedical research a growing number of platforms and technologies are
used to measure diverse but related information, and the task of clustering a set of objects …

Integrating transcriptome and proteome profiling: Strategies and applications

D Kumar, G Bansal, A Narang, T Basak, T Abbas… - …, 2016 - Wiley Online Library
Discovering the gene expression signature associated with a cellular state is one of the
basic quests in majority of biological studies. For most of the clinical and cellular …

[HTML][HTML] Complementary proteome and transcriptome profiling in phosphate-deficient Arabidopsis roots reveals multiple levels of gene regulation

P Lan, W Li, W Schmidt - Molecular & Cellular Proteomics, 2012 - Elsevier
Phosphate (P i) deficiency impairs plant growth and productivity in many agricultural
ecosystems, causing severe reductions in crop yield. To uncover novel aspects in …

Bayesian correlated clustering to integrate multiple datasets

P Kirk, JE Griffin, RS Savage, Z Ghahramani… - …, 2012 - academic.oup.com
Motivation: The integration of multiple datasets remains a key challenge in systems biology
and genomic medicine. Modern high-throughput technologies generate a broad array of …

Extracellular matrix and liver disease

E Arriazu, M Ruiz de Galarreta, FJ Cubero… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: The extracellular matrix (ECM) is a dynamic microenvironment that undergoes
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …

Orchestration of transcriptome, proteome and metabolome in the diatom Phaeodactylum tricornutum during nitrogen limitation

IM Remmers, S D'Adamo, DE Martens, RCH de Vos… - Algal Research, 2018 - Elsevier
Nitrogen deprivation increases the triacylglycerol (TAG) content in microalgae but also
severely decreases the growth rate. Most approaches that attempted to increase TAG …

Multi-dimensional liquid chromatography in proteomics—a review

X Zhang, A Fang, CP Riley, M Wang, FE Regnier… - Analytica chimica …, 2010 - Elsevier
Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …