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Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment
H Rodriguez, JC Zenklusen, LM Staudt, JH Doroshow… - Cell, 2021 - cell.com
When it comes to precision oncology, proteogenomics may provide better prospects to the
clinical characterization of tumors, help make a more accurate diagnosis of cancer, and …
clinical characterization of tumors, help make a more accurate diagnosis of cancer, and …
Integrated analysis of transcriptomic and proteomic data
Until recently, understanding the regulatory behavior of cells has been pursued through
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …
Bayesian consensus clustering
Motivation: In biomedical research a growing number of platforms and technologies are
used to measure diverse but related information, and the task of clustering a set of objects …
used to measure diverse but related information, and the task of clustering a set of objects …
Integrating transcriptome and proteome profiling: Strategies and applications
Discovering the gene expression signature associated with a cellular state is one of the
basic quests in majority of biological studies. For most of the clinical and cellular …
basic quests in majority of biological studies. For most of the clinical and cellular …
[HTML][HTML] Complementary proteome and transcriptome profiling in phosphate-deficient Arabidopsis roots reveals multiple levels of gene regulation
P Lan, W Li, W Schmidt - Molecular & Cellular Proteomics, 2012 - Elsevier
Phosphate (P i) deficiency impairs plant growth and productivity in many agricultural
ecosystems, causing severe reductions in crop yield. To uncover novel aspects in …
ecosystems, causing severe reductions in crop yield. To uncover novel aspects in …
Bayesian correlated clustering to integrate multiple datasets
Motivation: The integration of multiple datasets remains a key challenge in systems biology
and genomic medicine. Modern high-throughput technologies generate a broad array of …
and genomic medicine. Modern high-throughput technologies generate a broad array of …
Extracellular matrix and liver disease
E Arriazu, M Ruiz de Galarreta, FJ Cubero… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: The extracellular matrix (ECM) is a dynamic microenvironment that undergoes
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …
Orchestration of transcriptome, proteome and metabolome in the diatom Phaeodactylum tricornutum during nitrogen limitation
IM Remmers, S D'Adamo, DE Martens, RCH de Vos… - Algal Research, 2018 - Elsevier
Nitrogen deprivation increases the triacylglycerol (TAG) content in microalgae but also
severely decreases the growth rate. Most approaches that attempted to increase TAG …
severely decreases the growth rate. Most approaches that attempted to increase TAG …
Multi-dimensional liquid chromatography in proteomics—a review
Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …
functions. This still-emerging combination of technologies aims to describe and characterize …