Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …

The ongoing outbreak of the novel coronavirus disease (COVID-19) has spread globally and
poses a threat to public health in more than 200 countries. Reliable laboratory diagnosis of …

Molecular communication in biology is mediated by protein interactions. According to the
current paradigm, the specificity and affinity required for these interactions are encoded in …

Protein–protein association is fundamental to many life processes. However, a microscopic
model describing the structures and kinetics during association and dissociation is lacking …

Much of life's complexity depends upon contacts between proteins with precise affinity and
specificity. The successful application of engineered proteins often depends on high-stability …

Proteins span an extraordinary range of shapes, sizes and functionalities. Therefore generic
approaches are needed to overcome this diversity and stream-line protein analysis or …

The interior of a living cell is a crowded, heterogenuous, fluctuating environment. Hence, a
major challenge in modeling intracellular transport is to analyze stochastic processes within …

Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …