The role of lipids in Parkinson's disease
H **coy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
Brain cannabinoid receptor 2: expression, function and modulation
Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of
molecules, some with psychoactive effects. At least 4% of the world's adult population uses …
molecules, some with psychoactive effects. At least 4% of the world's adult population uses …
European Pain Federation (EFIC) position paper on appropriate use of cannabis‐based medicines and medical cannabis for chronic pain management
W Häuser, DP Finn, E Kalso… - … Journal of Pain, 2018 - Wiley Online Library
Cannabis‐based medicines are being approved for pain management in an increasing
number of European countries. There are uncertainties and controversies on the role and …
number of European countries. There are uncertainties and controversies on the role and …
New insights and potential therapeutic targeting of CB2 cannabinoid receptors in CNS disorders
The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in
the regulation of mental health. Consequently, its dysregulation is associated with …
the regulation of mental health. Consequently, its dysregulation is associated with …
Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone …
The cannabinoid type two receptors (CB2), an important component of the endocannabinoid
system, have recently emerged as neuromodulators and therapeutic targets for …
system, have recently emerged as neuromodulators and therapeutic targets for …
Cannabinoids and pain: sites and mechanisms of action
The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
The cannabinoid system and microglia in health and disease
Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …
immune cells of the central nervous system (CNS). Microglia are key players in CNS …
Neurotransmitter receptors on microglia
As the resident immune cells in the central nervous system, microglia have long been
hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this …
hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this …
Lipidomics of bioactive lipids in Alzheimer's and Parkinson's diseases: Where are we?
V Chiurchiù, M Tiberi, A Matteocci, F Fazio… - International Journal of …, 2022 - mdpi.com
Lipids are not only constituents of cellular membranes, but they are also key signaling
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …
[HTML][HTML] The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases
V Chiurchiù, M van der Stelt, D Centonze… - Progress in …, 2018 - Elsevier
Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …
nervous system, caused by an autoimmune response against myelin that eventually leads to …