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Targeting ferroptosis opens new avenues for the development of novel therapeutics
S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
[HTML][HTML] Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
The role of platelets in immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Y Liu, Y Wan, Y Jiang, L Zhang, W Cheng - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …
The diversified role of mitochondria in ferroptosis in cancer
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …
and it has been studied extensively since its discovery in 2012. Induced by iron overload …
Recent progress in ferroptosis: inducers and inhibitors
Y Du, Z Guo - Cell death discovery, 2022 - nature.com
Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron
accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous …
accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous …
Ironing out the role of ferroptosis in immunity
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many
diseases. Oxidative stress is detectable in many types of regulated cell death, but only …
diseases. Oxidative stress is detectable in many types of regulated cell death, but only …
Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds
T Wei, T Pan, X Peng, M Zhang, R Guo, Y Guo… - Nature …, 2024 - nature.com
Diabetic foot ulcers often become infected, leading to treatment complications and increased
risk of loss of limb. Therapeutics to manage infection and simultaneously promote healing …
risk of loss of limb. Therapeutics to manage infection and simultaneously promote healing …