Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

[HTML][HTML] Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

The role of platelets in immune-mediated inflammatory diseases

M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Y Liu, Y Wan, Y Jiang, L Zhang, W Cheng - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

The diversified role of mitochondria in ferroptosis in cancer

Y Liu, S Lu, L Wu, L Yang, L Yang, J Wang - Cell death & disease, 2023 - nature.com
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Recent progress in ferroptosis: inducers and inhibitors

Y Du, Z Guo - Cell death discovery, 2022 - nature.com
Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron
accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous …

Ironing out the role of ferroptosis in immunity

HN Bell, BR Stockwell, W Zou - Immunity, 2024 - cell.com
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many
diseases. Oxidative stress is detectable in many types of regulated cell death, but only …

Systemic lupus erythematosus pathogenesis: interferon and beyond

S Caielli, Z Wan, V Pascual - Annual review of immunology, 2023 - annualreviews.org
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

A guideline on the molecular ecosystem regulating ferroptosis

E Dai, X Chen, A Linkermann, X Jiang, R Kang… - Nature cell …, 2024 - nature.com
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds

T Wei, T Pan, X Peng, M Zhang, R Guo, Y Guo… - Nature …, 2024 - nature.com
Diabetic foot ulcers often become infected, leading to treatment complications and increased
risk of loss of limb. Therapeutics to manage infection and simultaneously promote healing …