Transcription factors serve critical roles in the progressive development of general body
plan, organ commitment, and finally, specific cell types. It has been the hope of most …

The DNA-binding domains of eukaryotic transcriptional activators play a key role in selective
promoter activation by tethering activation domains to the appropriate promoters and by …

Abstract The Oct-3/4 transcription factor sustains embryonic stem (ES) cell self-renewal and
is a dose-dependent cell fate determinant. In the adult male, its expression is restricted to …

POU transcription factors are involved in transcriptional regulation during early embryonic
development and cell differentiation. Oct-4, a member of this family, has been shown to be …

UTF1 is a transcriptional coactivator which has recently been isolated and found to be
expressed mainly in pluripotent embryonic stem (ES) cells (A. Okuda, A. Fukushima, M …

The POU transcription factor Oct-4 is expressed specifically in the germ line, pluripotent cells
of the pregastrulation embryo and stem cell lines derived from the early embryo. Osteopontin …

Normal and neoplastic growth of the prostate gland are dependent on androgen receptor
(AR) expression and function. Androgenic activation of the AR, in association with its …

The terminal differentiation of myelinating glia involves complex interactions that culminate
in the formation of myelin. The POU domain transcription factor Tst-1/Oct-6/SCIP is …

Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to
the cerebral cortex. DCAMKL1 consists of an N terminus that is 65% similar to DCX …

We use the LPS-stimulated macrophage as a model of inflammation to investigate the anti-
inflammatory effects of tomatidine and solasodine, whose structures resemble …