Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

During olfactory learning in fruit flies, dopaminergic neurons assign value to odor
representations in the mushroom body Kenyon cells. Here we identify a class of downstream …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Brain function relies on fast and precisely timed synaptic vesicle (SV) release at active zones
(AZs). Efficacy of SV release depends on distance from SV to Ca2+ channel, but molecular …

Sleep-promoting neurons in the dorsal fan-shaped body (dFB) of Drosophila are integral to
sleep homeostasis, but how these cells impose sleep on the organism is unknown. We …

The fruit fly can evaluate its energy state and decide whether to pursue food-related cues.
Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to …

The formation of mammalian synapses entails the precise alignment of presynaptic release
sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly …

The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic
active zone (AZ) membranes has been studied in detail, and several essential components …