The physiology, signaling, and pharmacology of dopamine receptors
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …
Modulation of striatal projection systems by dopamine
CR Gerfen, DJ Surmeier - Annual review of neuroscience, 2011 - annualreviews.org
The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal
projection systems—so-called direct and indirect pathways—form the functional backbone of …
projection systems—so-called direct and indirect pathways—form the functional backbone of …
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
In this review we propose that there are sex differences in how men and women enter onto
the path that can lead to addiction. Males are more likely than females to engage in risky …
the path that can lead to addiction. Males are more likely than females to engage in risky …
Striatal synapses, circuits, and Parkinson's disease
Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …
Dopaminergic modulation of striatal networks in health and Parkinson's disease
DJ Surmeier, SM Graves, W Shen - Current opinion in neurobiology, 2014 - Elsevier
Highlights•Spiny projection neurons do not just differ in their expression of dopamine
receptors.•The signaling mechanisms controlling synaptic plasticity are diverse.•Cholinergic …
receptors.•The signaling mechanisms controlling synaptic plasticity are diverse.•Cholinergic …
Dopaminergic modulation of striatal function and Parkinson's disease
The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a
diverse array of cellular and synaptic functions that control goal-directed actions and habits …
diverse array of cellular and synaptic functions that control goal-directed actions and habits …
Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility
Dopamine (DA) plays an essential role in the control of coordinated movements. Alterations
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …
An improved BAC transgenic fluorescent reporter line for sensitive and specific identification of striatonigral medium spiny neurons
KK Ade, Y Wan, M Chen, B Gloss… - Frontiers in systems …, 2011 - frontiersin.org
The development of BAC transgenic mice expressing promoter-specific fluorescent reporter
proteins has been a great asset for neuroscience by enabling detection of neuronal subsets …
proteins has been a great asset for neuroscience by enabling detection of neuronal subsets …
Dopaminergic modulation of striatal neurons, circuits, and assemblies
In recent years, there has been a great deal of progress toward understanding the role of the
striatum and dopamine in action selection. The advent of new animal models and the …
striatum and dopamine in action selection. The advent of new animal models and the …
Region-specific and state-dependent action of striatal GABAergic interneurons
E Fino, M Vandecasteele, S Perez, F Saudou… - Nature …, 2018 - nature.com
Striatum processes a wide range of functions including goal-directed behavior and habit
formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral …
formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral …