EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing …

GK Bertsias, JPA Ioannidis, M Aringer… - Annals of the …, 2010 - ard.bmj.com
Objectives To develop recommendations for the diagnosis, prevention and treatment of
neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations. Methods The …

Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers

H Jeltsch-David, S Muller - Nature Reviews Neurology, 2014 - nature.com
Systemic lupus erythematosus (SLE) is a complex clinical syndrome, elements of which
remain poorly understood. Although recognized over 140 years ago when Kaposi recorded …

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

Z Liu, A Davidson - Nature medicine, 2012 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …

Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects

E Cozzani, M Drosera, G Gasparini… - Autoimmune …, 2014 - Wiley Online Library
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
aberrant production of a broad and heterogenous group of autoantibodies. Even though the …

Autoantibodies in SLE: specificities, isotypes and receptors

B Dema, N Charles - Antibodies, 2016 - mdpi.com
Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …

Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations

GK Bertsias, DT Boumpas - Nature Reviews Rheumatology, 2010 - nature.com
Neuropsychiatric events are common in patients with systemic lupus erythematosus (SLE),
but less than one-third of these events can be directly attributed to SLE. Increased …

The diagnosis and clinical management of the neuropsychiatric manifestations of lupus

M Govoni, A Bortoluzzi, M Padovan, E Silvagni… - Journal of …, 2016 - Elsevier
Neuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a
severe and troubling manifestation of the disease that heavily impacts patient's health …

Losing your nerves? Maybe it's the antibodies

B Diamond, PT Huerta, P Mina-Osorio… - Nature Reviews …, 2009 - nature.com
We propose that the normal immunocompetent B cell repertoire is replete with B cells
making antibodies that recognize brain antigens. Although B cells that are reactive with self …

Cognitive dysfunction in systemic lupus erythematosus: immunopathology, clinical manifestations, neuroimaging and management

D Seet, NA Allameen, SH Tay, J Cho, A Mak - Rheumatology and Therapy, 2021 - Springer
Cognitive dysfunction (CD) is a common yet often clinically subtle manifestation that
considerably impacts the health-related quality of life in patients with systemic lupus …

Brain-reactive antibodies and disease

B Diamond, G Honig, S Mader… - Annual review of …, 2013 - annualreviews.org
Autoimmune diseases currently affect 5–7% of the world's population; in most diseases
there are circulating autoantibodies. Brain-reactive antibodies are present in approximately …