The G protein-coupled oestrogen receptor GPER in health and disease: an update
Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …
Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …
G protein–coupled estrogen receptor GPER: molecular pharmacology and therapeutic applications
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …
Sexual dimorphism in colon cancer
M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases
Prioritization of disease mechanisms, biomarkers, and drug targets in immune-mediated
inflammatory diseases (IMIDs) is complicated by altered interactions between thousands of …
inflammatory diseases (IMIDs) is complicated by altered interactions between thousands of …
Comprehensive profiling of Lingzhihuang capsule by liquid chromatography coupled with mass spectrometry-based molecular networking and target prediction
M Huang, S Yu, Q Shao, H Liu, Y Wang… - … and Herbal Medicine, 2022 - journals.lww.com
Objective: Lingzhihuang capsule (LZHC) is a natural product that consists of 10 commonly
used medicinal plants, and it is used in traditional Chinese medicine to promote people's …
used medicinal plants, and it is used in traditional Chinese medicine to promote people's …
Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine
WA Goodman, SM Bedoyan… - Proceedings of the …, 2020 - National Acad Sciences
Signaling of 17β-estradiol (estrogen) through its two nuclear receptors, α and β (ERα, ERβ),
is an important mechanism of transcriptional regulation. Although ERs are broadly …
is an important mechanism of transcriptional regulation. Although ERs are broadly …
Environmental estrogens and their biological effects through GPER mediated signal pathways
Y Qie, W Qin, K Zhao, C Liu, L Zhao, LH Guo - Environmental Pollution, 2021 - Elsevier
Many environmental chemicals have been found to exert estrogenic effects in cells and
experimental animals by activating nuclear receptors such as estrogen receptors and …
experimental animals by activating nuclear receptors such as estrogen receptors and …
Sex difference of colon adenoma pathway and colorectal carcinogenesis
Y Choi, N Kim - The World Journal of Men's Health, 2023 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …
sexes but shows sex differences. First, sex-specific differences in tumor recurrence and …
Endocrine disruption in Crohn's disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota …
The relevance of environmental triggers in Crohn's disease remains poorly explored,
despite the well‐known association between industrialization and disease …
despite the well‐known association between industrialization and disease …