Hepatocellular carcinoma (HCC) is a rising worldwide cause of cancer mortality, making the
elucidation of its underlying mechanisms an urgent priority. The liver is unique in its …

Stem cells have been identified as a source of virtually all highly differentiated cells that are
replenished during the lifetime of an animal. The critical balance between stem and …

Sensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise
connectivity, to transform sensation into compensatory behavior. Whether and how motor …

Locomotion requires precise control of the strength and speed of muscle contraction and is
achieved by recruiting functionally distinct subtypes of motor neurons (MNs). MNs are …

Understanding the principles governing neuronal diversity is a fundamental goal for
neuroscience. Here, we provide an anatomical and transcriptomic database of nearly 200 …

Cultured ESCs can form different classes of neurons, but whether these neurons can
acquire specialized subtype features typical of neurons in vivo remains unclear. We show …

Richness of neural circuits and specificity of neuronal connectivity depend on the
diversification of nerve cells into functionally and molecularly distinct subtypes. Although …

Motor neuron diseases (MNDs) are a heterogeneous group of disorders that affect the
cranial and/or spinal motor neurons (spMNs), spinal sensory neurons and the muscular …

How the vast array of neuronal diversity is generated remains an unsolved problem. Here,
we investigate how 29 morphologically distinct leg motoneurons are generated from a single …

According to experts in neurology, brain tumours pose a serious risk to human health. The
clinical identification and treatment of brain tumours rely heavily on accurate segmentation …