The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Integrating old and new paradigms of G1/S control
Summary The Cdk-Rb-E2F pathway integrates external and internal signals to control
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …
Fundamental trade-offs between information flow in single cells and cellular populations
Signal transduction networks allow eukaryotic cells to make decisions based on information
about intracellular state and the environment. Biochemical noise significantly diminishes the …
about intracellular state and the environment. Biochemical noise significantly diminishes the …
A precise Cdk activity threshold determines passage through the restriction point
At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed
as a point in G1 that is passed when growth factor signaling initiates a positive feedback …
as a point in G1 that is passed when growth factor signaling initiates a positive feedback …
Spatial and temporal signal processing and decision making by MAPK pathways
Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast to man and
regulate a variety of cellular processes, including proliferation and differentiation. Recent …
regulate a variety of cellular processes, including proliferation and differentiation. Recent …
Learning of signaling networks: molecular mechanisms
Molecular processes of neuronal learning have been well described. However, learning
mechanisms of non-neuronal cells are not yet fully understood at the molecular level. Here …
mechanisms of non-neuronal cells are not yet fully understood at the molecular level. Here …
Bistability of somatic pattern memories: stochastic outcomes in bioelectric circuits underlying regeneration
G Pezzulo, J LaPalme, F Durant… - … Transactions of the …, 2021 - royalsocietypublishing.org
Nervous systems' computational abilities are an evolutionary innovation, specializing and
speed-optimizing ancient biophysical dynamics. Bioelectric signalling originated in cells' …
speed-optimizing ancient biophysical dynamics. Bioelectric signalling originated in cells' …
[HTML][HTML] Epigenetic inheritance of gene silencing is maintained by a self-tuning mechanism based on resource competition
Biological systems can maintain memories over long timescales, with examples including
memories in the brain and immune system. It is unknown how functional properties of …
memories in the brain and immune system. It is unknown how functional properties of …
CDK and MAPK synergistically regulate signaling dynamics via a shared multi-site phosphorylation region on the scaffold protein Ste5
We report an unanticipated system of joint regulation by cyclin-dependent kinase (CDK) and
mitogen-activated protein kinase (MAPK), involving collaborative multi-site phosphorylation …
mitogen-activated protein kinase (MAPK), involving collaborative multi-site phosphorylation …
The genetics of epigenetic inheritance: modes, molecules, and mechanisms
S Schaefer, JH Nadeau - The Quarterly review of biology, 2015 - journals.uchicago.edu
Organisms adapt developmental and physiological features to local and transient conditions
in part by modulating transcription, translation, and protein functions, usually without …
in part by modulating transcription, translation, and protein functions, usually without …