Cardiac fibroblast p38 MAPK: a critical regulator of myocardial remodeling
NA Turner, NM Blythe - Journal of cardiovascular development and …, 2019 - mdpi.com
The cardiac fibroblast is a remarkably versatile cell type that coordinates inflammatory,
fibrotic and hypertrophic responses in the heart through a complex array of intracellular and …
fibrotic and hypertrophic responses in the heart through a complex array of intracellular and …
Application of emetine in SARS-CoV-2 treatment: Regulation of p38 MAPK signaling pathway for preventing emetine-induced cardiac complications
Emetine is one of the most highly potent anti-SARS-CoV-2 agents ever identified. In addition
to having strong anti-SARS-CoV-2 activities, emetine has other valuable therapeutic effects …
to having strong anti-SARS-CoV-2 activities, emetine has other valuable therapeutic effects …
Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer
D Morgan, KL Berggren, CD Spiess… - Molecular …, 2022 - Wiley Online Library
Cancer and the immune system share an intimate relationship. Chronic inflammation
increases the risk of cancer occurrence and can also drive inflammatory mediators into the …
increases the risk of cancer occurrence and can also drive inflammatory mediators into the …
MK2 inhibitors as a potential Crohn's disease treatment approach for regulating MMP expression, cleavage of checkpoint molecules and T cell activity
EJ Lebish, NJ Morgan, JF Valentine, EJ Beswick - Pharmaceuticals, 2022 - mdpi.com
Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two major forms of inflammatory
bowel disease (IBD), which are incurable chronic immune-mediated diseases of the …
bowel disease (IBD), which are incurable chronic immune-mediated diseases of the …
Mitogen-activated protein kinase–activated protein kinase 2 inhibition attenuates fibroblast invasion and severe lung fibrosis
Severe pulmonary fibrosis such as idiopathic pulmonary fibrosis (IPF) is characterized by the
accumulation of extracellular matrix and fibroblast activation. Targeting fibroblast activation …
accumulation of extracellular matrix and fibroblast activation. Targeting fibroblast activation …
Network model integrated with multi-omic data predicts MBNL1 signals that drive myofibroblast activation
RNA-binding protein muscleblind-like1 (MBNL1) was recently identified as a central
regulator of cardiac wound healing and myofibroblast activation. To identify putative MBNL1 …
regulator of cardiac wound healing and myofibroblast activation. To identify putative MBNL1 …
Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease
M Chulkina, C Rohmer, S McAninch… - Journal of Crohn's …, 2024 - academic.oup.com
Background Mesenchymal stromal cells are suggested to play a critical role in Crohn's
disease [CD]-associated fibrosis. MAPKAPK2 [MK2] has emerged as a potential therapeutic …
disease [CD]-associated fibrosis. MAPKAPK2 [MK2] has emerged as a potential therapeutic …
MMI-0100 ameliorates dextran sulfate sodium-induced colitis in mice through targeting MK2 pathway
Z Wang, XY Liang, X Chang, YY Nie, C Guo, JH Jiang… - Molecules, 2019 - mdpi.com
Backgrounds: This study aimed to investigate the protective effects of MMI-0100, a cell-
penetrating peptide inhibitor of MAPK-activated protein kinase II (MK2), on acute colitis …
penetrating peptide inhibitor of MAPK-activated protein kinase II (MK2), on acute colitis …
MK2 deficiency decreases mortality during the inflammatory phase after myocardial infarction in mice
J Trépanier, SA Nawaito, P Sahadevan, F Sahmi… - bioRxiv, 2023 - biorxiv.org
Background: Altering the onset, intensity, or duration of inflammation can impact the
recovering heart's structure and function following myocardial infarction (MI). Substrates of …
recovering heart's structure and function following myocardial infarction (MI). Substrates of …
[CITATION][C] Research advances in the mechanism of action of myocardial endoplasmic reticulum stress in inducing arrhythmia
Z YaFei, LI Tao