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Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
poor patient survival. As our molecular understanding of gastric cancer improves, we are …
Pathogenesis and cells of origin of Barrett's esophagus
In patients with Barrett's esophagus (BE), metaplastic columnar mucosa containing epithelial
cells with gastric and intestinal features replaces esophageal squamous mucosa damaged …
cells with gastric and intestinal features replaces esophageal squamous mucosa damaged …
Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients
Objective Autoimmune gastritis (AIG) is an immunomediated disease targeting parietal cells,
eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at …
eventually resulting in oxyntic-restricted atrophy. This long-term follow-up study aimed at …
Mechanisms and pathophysiology of Barrett oesophagus
Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose
individuals to cancer development lines a portion of the distal oesophagus, is the only …
individuals to cancer development lines a portion of the distal oesophagus, is the only …
[HTML][HTML] Up-regulation of aquaporin 5 defines spasmolytic polypeptide-expressing metaplasia and progression to incomplete intestinal metaplasia
SH Lee, B Jang, J Min, EW Contreras-Panta… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Metaplasia in the stomach is highly associated with development of
intestinal-type gastric cancer. Two types of metaplasias, spasmolytic polypeptide-expressing …
intestinal-type gastric cancer. Two types of metaplasias, spasmolytic polypeptide-expressing …
Metaplastic Paneth cells in extra-intestinal mucosal niche indicate a link to microbiome and inflammation
Paneth cells are residents of the intestinal epithelium. Abnormal appearance of Paneth cells
has been widely documented in non-intestinal tissues within the digestive tract and even …
has been widely documented in non-intestinal tissues within the digestive tract and even …
From antimicrobial to anticancer peptides: the transformation of peptides
Y Qin, ZD Qin, J Chen, CG Cai, L Li… - Recent patents on …, 2019 - benthamdirect.com
Background: Antimicrobial peptides play an important role in the innate immune system.
Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat …
Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat …
Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients
There are two types of pyloric gland-like metaplasia in the corpus of stomach: pyloric and
pseudopyloric metaplasias. They show the same morphology as the original pyloric glands …
pseudopyloric metaplasias. They show the same morphology as the original pyloric glands …
Barrett's esophagus and intestinal metaplasia
L Zhang, B Sun, X Zhou, QQ Wei, S Liang, G Luo… - Frontiers in …, 2021 - frontiersin.org
Intestinal metaplasia refers to the replacement of the differentiated and mature normal
mucosal epithelium outside the intestinal tract by the intestinal epithelium. This paper briefly …
mucosal epithelium outside the intestinal tract by the intestinal epithelium. This paper briefly …
Shared features of metaplasia and the development of adenocarcinoma in the stomach and esophagus
Introduction: Plasticity is an inherent property of the normal gastrointestinal tract allowing for
appropriate response to injury and healing. However, the aberrancy of adaptable responses …
appropriate response to injury and healing. However, the aberrancy of adaptable responses …