The mitochondrial membrane potential (ΔΨm) generated by proton pumps (Complexes I, III
and IV) is an essential component in the process of energy storage during oxidative …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the
mitochondrial respiratory chain with antioxidant properties widely used as an antiaging …

Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS),
produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS …

Mitochondrial dysfunction plays a crucial role in the macroautophagy/autophagy cascade. In
a recently published study Sun et al. described the induction of autophagy by the …

Organ preservation has been of major importance ever since transplantation developed into
a global clinical activity. The relatively simple procedures were developed on a basic …

Renal disease affects millions of people worldwide, imposing an enormous financial burden
for health-care systems. Recent evidence suggests that mitochondria play an important role …

Induced and frequently unwanted alterations in the mitochondrial structure and functions are
a key component of the pathological cascade in many kidney pathologies, including those …