The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …

E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino
terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

One of the core standards of biochemistry is that the function of a protein relies on its 3D
structure. This idea posits that all the information required for a protein to perform its …

Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be
distinguished from other proteins in terms of lack of any fixed structure. Such dynamic …

Circular dichroism (CD) spectroscopy is a simple and powerful technique, which allows for
the assessment of the conformational properties of a protein or protein domain. Intrinsically …

Amyloidoses are an array of diseases associated with the aggregation of proteins into fibrils.
While it was previously thought that amyloid fibril-forming proteins are exclusively host-cell …

Many proteins or their regions are disordered in their native, biologically active states.
Bioinformatics has revealed that these proteins/regions are highly abundant in different …

The oncoprotein E7 from human papillomavirus (HPV) strains that confer high cancer risk
mediates cell transformation by deregulating host cellular processes and activating viral …

The Human papillomavirus (HPV) causes tumors in part by hijacking the host cell cycle and
forcing uncontrolled cellular division. While there are> 200 genotypes of HPV, 15 are …