Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

Recent surveillance data of multidrug-resistant tuberculosis (MDR-TB) reported the highest
rates of resistance ever documented. As further amplification of resistance in MDR strains of …

Background The continued advance of antibiotic resistance threatens the treatment and
control of many infectious diseases. This is exemplified by the largest global outbreak of …

Factors driving the increase in drug-resistant tuberculosis (TB) in the Eastern Cape
Province, South Africa, are not understood. A convenience sample of 309 drug-susceptible …

Rifampin resistance in clinical isolates of Mycobacterium tuberculosis arises primarily
through the selection of bacterial variants harboring mutations in the 81-bp rifampin …

Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts,
particularly in Africa where the disease remains out of control. The dogma that DR-TB …

Accelerating progress in the fight against tuberculosis will require a drastic shift from a
strategy focused on control to one focused on elimination. Successful disease elimination …

Background The year 2015 marked the end of United Nations Millennium Development
Goals which was aimed at halting and reversing worldwide tuberculosis (TB). The …

Objective To investigate the distribution of Mycobacterium tuberculosis genotypes across
Africa. Methods The SITVIT2 global repository and PUBMED were searched for spoligotype …

Numerous reports have documented isolated transmission events or clonal outbreaks of
multidrug-resistant Mycobacterium tuberculosis strains, but knowledge of their epidemic …