Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Historically, the primary focus of cancer research has been molecular and clinical studies of
a few essential pathways and genes. Recent years have seen the rapid accumulation of …

Abstract Background N6-methyladenosine (m6A) is the most common post-transcriptional
modification at the RNA level. However, the exact molecular mechanisms of m6A epigenetic …

Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The
elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing …

Precision oncology has made significant advances, mainly by targeting actionable mutations
in cancer driver genes. Aiming to expand treatment opportunities, recent studies have begun …

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

Amino acids play central roles in cancer progression beyond their function as building
blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been …

l‐Asparaginase (a hydrolase converting l‐asparagine to l‐aspartic acid) was the first
enzyme to be used in clinical practice as an anticancer agent after its approval in 1978 as a …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies with an
extremely poor prognosis. Energy metabolism reprogramming, an emerging hallmark of …

Tumour dependency on specific metabolic signals has been demonstrated and often guided
numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial …