Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are
ineffective in all cases. The genomic profile and biomarkers associated with the process are …

Background The pan-immune-inflammation value (PIV) has been reported as a novel
prognostic biomarker in multiple malignancies. The aim of this study is to investigate the …

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the United
States. Although immunotherapy has dramatically changed the landscape of treatment for …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Recent advancements
in genomic technologies and analytical approaches have revolutionized CRC research …

Esophageal cancer (EC) is a common malignant gastrointestinal (GI) cancer in adults.
Although surgical technology combined with neoadjuvant chemoradiotherapy has advanced …

Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …

Background Current prognostic prediction models of colorectal cancer (CRC) include only
the preoperative measurement of tumor markers, with their available repeated postoperative …

Microsatellite instability (MSI) became the spotlight after the US FDA's approval of MSI as an
indication of immunotherapy for cancer patients. Immunohistochemical detection of loss of …

Repeat expansion disorders (REDs) are monogenic diseases caused by a sequence of
repetitive DNA expanding above a pathogenic threshold. A common feature of the REDs is a …

TIM4 has previously been associated with antitumor immunity, yet the pattern of expression
and the function of this receptor across human cancer tissues remain poorly explored. Here …