As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …

Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …

Defective antioxidant system as well as mitochondrial dysfunction contributes to the
pathogenesis and progression of diabetic kidney disease (DKD). Nuclear factor erythroid 2 …

Diabetic kidney disease (DKD) is one of the most common complications of diabetes and is
clinically featured by progressive albuminuria, consequent to glomerular destruction that …

Over 10% of the global population suffers from kidney disease. However, only kidney
replacement therapies, which burden medical expenses, are currently effective in treating …

GSK3 has been implicated for years in the regulation of inflammation and addressed in a
plethora of scientific reports using a variety of experimental (disease) models and …

Hyperglycemia/oxidative stress has been implicated in the initiation and progression of
diabetic complications while the components of Keap1/Nrf2/ARE signaling are being …

Diabetic kidney disease (DKD) is among the most common complications of diabetes
mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in …

Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of
insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury …

NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …