The TFCP2/Grainyhead family of transcription factors is divided into two distinct subfamilies,
one of which includes the Grainyhead-like 1-3 (GRHL1-3) proteins and the other consists of …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

How animals (metazoans) originated from their single-celled ancestors remains a major
question in biology. As transcriptional regulation is crucial to animal development …

The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

Background In broiler production, breast muscle weight and intramuscular fat (IMF) content
are important economic traits. Understanding the genetic mechanisms that underlie these …

Hepatocellular carcinoma (HCC) is a prevalent and aggressive malignancy associated with
high risks of recurrence and metastasis. Liver cancer stem cells (CSCs) are increasingly …

The Grainyhead-like (GRHL) family of transcription factors has three mammalian members,
which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and …

Abstract Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular
organisms as key regulators of epithelial differentiation, organ development and skin barrier …

Coordinated changes in gene expression allow a single fertilized oocyte to develop into a
complex multi-cellular organism. These changes in expression are controlled by …

Abstract The Grainy head (Grh) family of transcription factors is characterized by a unique
DNA-binding domain that binds to a conserved consensus sequence. Nematodes and flies …