In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Mitochondria are highly dynamic organelles whose functions are essential for cell viability.
Within the cell, the mitochondrial network is continuously remodeled through the balance …

Mitochondrial architecture is involved in several functions crucial for cell viability,
proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the …

INTRODUCTION Mitochondria are essential organelles whose form and function are
inextricably linked. Balanced fusion and fission events shape mitochondria to meet …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …