Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Overview of therapeutic ultrasound applications and safety considerations

DL Miller, NB Smith, MR Bailey… - Journal of ultrasound …, 2012 - Wiley Online Library
Applications of ultrasound in medicine for therapeutic purposes have been accepted and
beneficial uses of ultrasonic biological effects for many years. Low‐power ultrasound of …

Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies

RJE van den Bijgaart, DC Eikelenboom… - Cancer Immunology …, 2017 - Springer
Tumor ablation technologies, such as radiofrequency-, cryo-or high-intensity focused
ultrasound (HIFU) ablation will destroy tumor tissue in a minimally invasive manner. Ablation …

[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy

KB Bader, E Vlaisavljevich, AD Maxwell - Ultrasound in medicine & biology, 2019 - Elsevier
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications

VA Khokhlova, JB Fowlkes, WW Roberts… - International journal …, 2015 - Taylor & Francis
In high intensity focused ultrasound (HIFU) therapy, an ultrasound beam is focused within
the body to locally affect the targeted site without damaging intervening tissues. The most …

Cavitation clouds created by shock scattering from bubbles during histotripsy

AD Maxwell, TY Wang, CA Cain, JB Fowlkes… - The Journal of the …, 2011 - pubs.aip.org
Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to
incite a localized cavitation cloud that mechanically breaks down tissue. To investigate the …

[KSIĄŻKA][B] Power ultrasonics: applications of high-intensity ultrasound

JA Gallego-Juárez, KF Graff, M Lucas - 2023 - books.google.com
Power Ultrasonics: Applications of High-Intensity Ultrasound, Second Edition provides a
comprehensive reference on the fundamentals, processing, engineering, medical, food and …

High-intensity focused ultrasound (HIFU) triggers immune sensitization of refractory murine neuroblastoma to checkpoint inhibitor therapy

A Eranki, P Srinivasan, M Ries, AR Kim… - Clinical Cancer …, 2020 - aacrjournals.org
Purpose: Immunotherapy promises unprecedented benefits to patients with cancer.
However, the majority of cancer types, including high-risk neuroblastoma, remain …

Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling

TD Khokhlova, MS Canney, VA Khokhlova… - The Journal of the …, 2011 - pubs.aip.org
In high intensity focused ultrasound (HIFU) applications, tissue may be thermally necrosed
by heating, emulsified by cavitation, or, as was recently discovered, emulsified using …

The histotripsy spectrum: differences and similarities in techniques and instrumentation

RP Williams, JC Simon, VA Khokhlova… - International Journal …, 2023 - Taylor & Francis
Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …