Chromatin features are widely used for genome-scale map** of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Transposable elements (TEs) are major contributors of genetic material in mammalian
genomes. These often include binding sites for architectural proteins, including the …

Highlights•Recent work indicates that chromatin compartments can finely segregate
genomic intervals that are 1–2 kb in size.•Evidence both supports and refutes several …

We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …

Regulatory elements are the genomic regions that interact with transcription factors to
control cell-type-specific gene expression in different cellular environments. A precise and …

Abstract Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET)
DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of …

Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …

Although DNA methylation data yields highly accurate age predictors, little is known about
the dynamics of this quintessential epigenomic biomarker during lifespan. To narrow the …

Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …

The arrival of the Infinium DNA methylation BeadChips for mice and other nonhuman
mammalian species has outpaced the development of the informatics that supports their use …