Active nematics across scales from cytoskeleton organization to tissue morphogenesis
Biological tissues are composed of various cell types working cooperatively to perform their
respective function within organs and the whole body. During development, embryogenesis …
respective function within organs and the whole body. During development, embryogenesis …
[HTML][HTML] Tug-of-war via ERK signaling pathway for tissue organization–ERK activation to force generation
AN Nayak, T Hirashima - Current Opinion in Cell Biology, 2023 - Elsevier
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …
Optogenetic activators of apoptosis, necroptosis, and pyroptosis
K Shkarina, E Hasel de Carvalho, JC Santos… - Journal of Cell …, 2022 - rupress.org
Targeted and specific induction of cell death in an individual or groups of cells hold the
potential for new insights into the response of tissues or organisms to different forms of …
potential for new insights into the response of tissues or organisms to different forms of …
Quantifying cell-generated forces: Poisson's ratio matters
Quantifying mechanical forces generated by cellular systems has led to key insights into a
broad range of biological phenomena from cell adhesion to immune cell activation. Traction …
broad range of biological phenomena from cell adhesion to immune cell activation. Traction …
Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation
The number of cells in tissues is controlled by cell division and cell death, and its
misregulation could lead to pathological conditions such as cancer. To maintain the cell …
misregulation could lead to pathological conditions such as cancer. To maintain the cell …
Epithelial apoptotic pattern emerges from global and local regulation by cell apical area
Geometry is a fundamental attribute of biological systems, and it underlies cell and tissue
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …
Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis
KW Pond, JM Morris, O Alkhimenok, RP Varghese… - Elife, 2022 - elifesciences.org
The establishment and maintenance of different cellular compartments in tissues is a
universal requirement across all metazoans. Maintaining the correct ratio of cell types in time …
universal requirement across all metazoans. Maintaining the correct ratio of cell types in time …
Interfacial organization and forces arising from epithelial–cancerous monolayer interactions
The interfacial interactions between epithelia and cancer cells have profound relevance for
tumor development and metastasis. Through monolayer confrontation of MCF10A …
tumor development and metastasis. Through monolayer confrontation of MCF10A …
The mechanical forces that shape our senses
Develo** organs are shaped, in part, by physical interaction with their environment in the
embryo. In recent years, technical advances in live-cell imaging and material science have …
embryo. In recent years, technical advances in live-cell imaging and material science have …
Collective effects in epithelial cell death and cell extrusion
Programmed cell death, notably apoptosis, is an essential guardian of tissue homeostasis
and an active contributor of organ sha**. While the regulation of apoptosis has been …
and an active contributor of organ sha**. While the regulation of apoptosis has been …