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Alzheimer's disease: exploring the landscape of cognitive decline
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is …
cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is …
RNA and condensates: Disease implications and therapeutic opportunities
Biomolecular condensates are dynamic membraneless organelles that compartmentalize
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …
Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins
MA Zeballos C, HJ Moore, TJ Smith, JE Powell… - Nature …, 2023 - nature.com
The TDP-43 proteinopathies, which include amyotrophic lateral sclerosis and frontotemporal
dementia, are a devastating group of neurodegenerative disorders that are characterized by …
dementia, are a devastating group of neurodegenerative disorders that are characterized by …
Optical control over liquid–liquid phase separation
L Jia, S Gao, Y Qiao - Small Methods, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS) is responsible for the emergence of intracellular
membrane‐less organelles and the development of coacervate protocells. Benefitting from …
membrane‐less organelles and the development of coacervate protocells. Benefitting from …
Seeding-competent TDP-43 persists in human patient and mouse muscle
EM Lynch, S Pittman, J Daw, C Ikenaga… - Science translational …, 2024 - science.org
TAR DNA binding protein 43 (TDP-43) is an RNA binding protein that accumulates as
aggregates in the central nervous systems of some patients with neurodegenerative …
aggregates in the central nervous systems of some patients with neurodegenerative …
TDP-43 proteinopathy specific biomarker development
I Cordts, A Wachinger, C Scialo, P Lingor… - Cells, 2023 - mdpi.com
TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …
Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models
CA Droppelmann, D Campos-Melo, V Noches… - Brain, 2024 - academic.oup.com
Aggregation of the RNA-binding protein TAR DNA binding protein (TDP-43) is a hallmark of
TDP-proteinopathies including amyotrophic lateral sclerosis (ALS) and frontotemporal …
TDP-proteinopathies including amyotrophic lateral sclerosis (ALS) and frontotemporal …
In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use
JI López-Carbonero, I García-Toledo… - Translational …, 2024 - Springer
TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that
share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43 …
share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43 …
[HTML][HTML] Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice
C Gonzalo-Consuegra, I Santos-García… - Biomedicine & …, 2024 - Elsevier
Background The elevation of endocannabinoid levels through inhibiting their degradation
afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of …
afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of …
The pathogenic mechanism of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis
X Wang, Y Hu, R Xu - Neural Regeneration Research, 2024 - journals.lww.com
The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both
upper and/or lower motor neurons occurring in the motor cortex, basal ganglia, brainstem …
upper and/or lower motor neurons occurring in the motor cortex, basal ganglia, brainstem …