Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Integrin-based adhesion has served as a model for studying the central role of adhesion in
migration. In this article, we outline modes of migration, both integrin-dependent and …

A central question in cell biology is how membrane-spanning receptors transmit
extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion …

Cell migration is a complex, highly regulated process that involves the continuous formation
and disassembly of adhesions (adhesion turnover). Adhesion formation takes place at the …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number
of human malignancies and has been linked to the development of cancer and progression …

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs),
including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK …

Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell
proliferation, cell survival and cell migration. Given that the development of malignancy is …

Cell motility is regulated by multiple processes, including cell protrusion, cell retraction, cell–
matrix adhesion, polarized exocytosis and polarized vesicle trafficking, each of which is …