Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress),
amino acid starvation, or oxidants by phosphorylating the α subunit of translation initiation …

Synergy occurs when the contribution of two mutations to the phenotype of a double mutant
exceeds the expectations from the additive effects of the individual mutations. The molecular …

Increased protection from reactive oxygen species (ROS) is believed to increase life span.
However, it has not been clearly demonstrated that endogenous ROS production actually …

DAF-16/forkhead transcription factor, the downstream target of the insulin-like signaling in
Caenorhabditis elegans, is indispensable for both lifespan regulation and stress resistance …

Recent studies on aging in model systems such as yeast and roundworms have revealed
conserved regulation of the process in response to nutrient availability and specific genes …

In Caenorhabditis elegans, longevity is increased by a partial loss‐of‐function mutation in
the mitochondrial complex III subunit gene isp‐1. Longevity is also increased by RNAi …

Dietary restriction (DR) increases life span in a wide variety of animals. In Caenorhabditis
elegans both reduced bacterial concentration (BDR) and culture on non-bacterial, semi …

Abstract SOD-1 and SOD-2 detoxify superoxide in the cytoplasm and mitochondria. We find
that, although several long-lived mutants of Caenorhabditis elegans have increased SOD …

The number of elderly people is increasing worldwide as well as the age-associated
diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients …

The zebrafish has emerged over the past decade as a major model system for the study of
development due to its invertebrate-like advantages coupled with its vertebrate biology …