Emerging perspectives on dipeptide repeat proteins in C9ORF72 ALS/FTD
A Schmitz, J Pinheiro Marques, I Oertig… - Frontiers in cellular …, 2021 - frontiersin.org
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 …
dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 …
Disease mechanisms of C9ORF72 repeat expansions
TF Gendron, L Petrucelli - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
G4C2 repeat expansions within the C9ORF72 gene are the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These …
C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration
S May, D Hornburg, MH Schludi, T Arzberger… - Acta …, 2014 - Springer
Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in
patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …
patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …
The Caenorhabditis elegans Lifespan Machine
N Stroustrup, BE Ulmschneider, ZM Nash… - Nature …, 2013 - nature.com
The measurement of lifespan pervades aging research. Because lifespan results from
complex interactions between genetic, environmental and stochastic factors, it varies widely …
complex interactions between genetic, environmental and stochastic factors, it varies widely …
An ARL3–UNC119–RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
The membrane of the primary cilium is a highly specialized compartment that organizes
proteins to achieve spatially ordered signaling. Disrupting ciliary organization leads to …
proteins to achieve spatially ordered signaling. Disrupting ciliary organization leads to …
[HTML][HTML] A primary culture system for functional analysis of C. elegans neurons and muscle cells
M Christensen, A Estevez, X Yin, R Fox, R Morrison… - Neuron, 2002 - cell.com
C. elegans has provided important insights into neuromuscular system function and
development. However, the animal's small size limits access to individual neurons and …
development. However, the animal's small size limits access to individual neurons and …
Genome-wide association study of sleep in Drosophila melanogaster
ST Harbison, LJ McCoy, TFC Mackay - BMC genomics, 2013 - Springer
Background Sleep is a highly conserved behavior, yet its duration and pattern vary
extensively among species and between individuals within species. The genetic basis of …
extensively among species and between individuals within species. The genetic basis of …
Sensory Ciliogenesis in Caenorhabditis elegans: Assignment of IFT Components into Distinct Modules Based on Transport and Phenotypic Profiles
Sensory cilium biogenesis within Caenorhabditis elegans neurons depends on the kinesin-
2–dependent intraflagellar transport (IFT) of ciliary precursors associated with IFT particles …
2–dependent intraflagellar transport (IFT) of ciliary precursors associated with IFT particles …
Syndecan regulates cell migration and axon guidance in C. elegans
C Rhiner, S Gysi, E Fröhli, MO Hengartner, A Hajnal - 2005 - journals.biologists.com
During nervous system development, axons that grow out simultaneously in the same
extracellular environment are often sorted to different target destinations. As there is only a …
extracellular environment are often sorted to different target destinations. As there is only a …
Highly efficient RNAi and Cas9-based auto-cloning systems for C. elegans research
RNA interference (RNAi) technology used for the functional analysis of Caenorhabditis
elegans genes frequently leads to phenotypes with low penetrance or even proves …
elegans genes frequently leads to phenotypes with low penetrance or even proves …