Respiratory neuroplasticity–Overview, significance and future directions

DD Fuller, GS Mitchell - Experimental neurology, 2017 - Elsevier
Neuroplasticity is an important property of the neural system controlling breathing. However,
our appreciation for its importance is still relatively new, and we have much to learn …

V2a neurons restore diaphragm function in mice following spinal cord injury

VN Jensen, EE Huffman, FL Jalufka… - Proceedings of the …, 2024 - pnas.org
The specific roles that different types of neurons play in recovery from injury is poorly
understood. Here, we show that increasing the excitability of ipsilaterally projecting …

Respiration following spinal cord injury: evidence for human neuroplasticity

DJ Hoh, LM Mercier, SP Hussey, MA Lane - Respiratory physiology & …, 2013 - Elsevier
Respiratory dysfunction is one of the most devastating consequences of cervical spinal cord
injury (SCI) with impaired breathing being a leading cause of morbidity and mortality in this …

Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury

A Navarrete-Opazo, S Vinit, BJ Dougherty… - Experimental …, 2015 - Elsevier
A major cause of mortality after spinal cord injury is respiratory failure. In normal rats, acute
intermittent hypoxia (AIH) induces respiratory motor plasticity, expressed as diaphragm (Dia) …

Respiratory function following bilateral mid-cervical contusion injury in the adult rat

MA Lane, KZ Lee, K Salazar, BE O'Steen… - Experimental …, 2012 - Elsevier
The consequences of spinal cord injury (SCI) are often viewed as the result of white matter
damage. However, injuries occurring at any spinal level, especially in cervical and lumbar …

Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats

MJ Fogarty, WZ Zhan, CB Mantilla… - Physiological …, 2024 - Wiley Online Library
Cervical spinal cord injury impacts ventilatory and non‐ventilatory functions of the
diaphragm muscle (DIAm) and contributes to clinical morbidity and mortality in the afflicted …

Enhanced recovery of breathing capacity from combined adenosine 2A receptor inhibition and daily acute intermittent hypoxia after chronic cervical spinal injury

A Navarrete-Opazo, BJ Dougherty, GS Mitchell - Experimental neurology, 2017 - Elsevier
Daily acute intermittent hypoxia (dAIH) improves breathing capacity after C2 spinal
hemisection (C2HS) in rats. Since C2HS disrupts spinal serotonergic innervation below the …

[HTML][HTML] Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection

K Satkunendrarajah, F Nassiri, SK Karadimas… - Experimental …, 2016 - Elsevier
Cervical spinal cord injury (SCI) can result in devastating functional deficits that involve the
respiratory and hand function. The mammalian spinal cord has limited ability to regenerate …

Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats

T Bezdudnaya, KM Hormigo, V Marchenko… - Experimental …, 2018 - Elsevier
Unilateral cervical C2 hemisection (C2Hx) is a classic model of spinal cord injury (SCI) for
studying respiratory dysfunction and plasticity. However, most previous studies were …

Spinal cord injury and diaphragm neuromotor control

MJ Fogarty, GC Sieck - Expert review of respiratory medicine, 2020 - Taylor & Francis
Introduction: Neuromotor control of diaphragm muscle and the recovery of diaphragm
activity following spinal cord injury have been narrowly focused on ventilation. By contrast …