Currently microorganisms are best identified using 16S rRNA and 18S rRNA gene
sequencing. However, in recent years matrix assisted laser desorption ionization-time of …

The recent sequencing of the entire genomes of Mycoplasma genitalium and M.
pneumoniae has attracted considerable attention to the molecular biology of mycoplasmas …

The advent of large genolne sequencing projects has changed the scale of biology. Over a
relatively short period of tinle, we have witnessed the elucidation of the conlplete nucleotide …

The emergence of proteomics, the large-scale analysis of proteins, has been inspired by the
realization that the final product of a gene is inherently more complex and closer to function …

Separation and identification of proteins by two-dimensional (2-D) electrophoresis can be
used for protein-based gene expression analysis. In this report single protein spots, from …

Genome sequencing provides a wealth of information on predicted gene products (mostly
proteins), but the majority of these have no known function. Two-dimensional gel …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

In recent decades, the worldwide prevalence of obesity has risen dramatically and is
currently estimated to be around 20%. Obesity is linked to an increased risk of comorbidities …

The pharmaceutical industry faces unsustainable program failure despite significant
increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets …

The evolution of mass spectrometry–based proteomic technologies has advanced our
understanding of the complex and dynamic nature of proteomes while concurrently …