Molecular profiling of endometrial cancer from TCGA to clinical practice
A Jamieson, JN McAlpine - Journal of the National Comprehensive …, 2023 - jnccn.org
Molecular classification provides an objective, reproducible framework for categorization of
endometrial cancers (ECs), informing prognosis and selection of therapy. Currently, the …
endometrial cancers (ECs), informing prognosis and selection of therapy. Currently, the …
Lynch Syndrome and Gynecologic tumors: incidence, Prophylaxis, and management of patients with Cancer
I Capasso, A Santoro, E Lucci Cordisco, E Perrone… - Cancers, 2023 - mdpi.com
Simple Summary Lynch syndrome (LS) is a genetic condition predisposing to a variety of
tumors, including endometrial (EC) and ovarian cancers (OC), with cancer lifetime risk …
tumors, including endometrial (EC) and ovarian cancers (OC), with cancer lifetime risk …
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere
I Bruchim, I Capasso, A Polonsky, S Meisel… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Endometrial cancer (EC) is the only gynecologic malignancy showing
increasing trends in incidence and mortality. While standard treatment has been effective …
increasing trends in incidence and mortality. While standard treatment has been effective …
Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer
JFG Bejar, EY Galende, Q Zeng… - Journal for …, 2024 - pmc.ncbi.nlm.nih.gov
Background Patients with mismatch repair-deficient (MMRd) endometrial cancer (EC) can
derive great benefit from immune checkpoint inhibitors (ICI). However not all responses and …
derive great benefit from immune checkpoint inhibitors (ICI). However not all responses and …
A tale of two pathways: Review of immune checkpoint inhibitors in DNA mismatch repair‐deficient and microsatellite instability‐high endometrial cancers
YL Liu, B Weigelt - Cancer, 2024 - Wiley Online Library
The DNA mismatch repair (MMR) pathway is critical for correcting DNA mismatches
generated during DNA replication. MMR‐deficiency (MMR‐D) leads to microsatellite …
generated during DNA replication. MMR‐deficiency (MMR‐D) leads to microsatellite …
[HTML][HTML] The evolving role of immune checkpoint inhibitors in cervical and endometrial cancer
The introduction of immune checkpoint inhibitors (ICIs) has revolutionized the treatment
landscape for numerous tumor types, including cervical and endometrial cancers. Multiple …
landscape for numerous tumor types, including cervical and endometrial cancers. Multiple …
Latest advances in immuno-oncology for endometrial cancer: single-agent and combination regimens
M Richardson, DM Chase - Current Opinion in Obstetrics and …, 2024 - journals.lww.com
The publication of the TCGA has led to significant focus on molecular subgrou**s into
POLEm, MMRd, NSMP, and p53m groups. For those patients with MMRd vs. MMRp tumors …
POLEm, MMRd, NSMP, and p53m groups. For those patients with MMRd vs. MMRp tumors …
[HTML][HTML] Digging into phenotype change in mismatch repair deficient endometrial carcinoma and treatment with immune checkpoint inhibition, a case report
M Rey-Cárdenas, L Parrilla-Rubio… - Gynecologic …, 2023 - ncbi.nlm.nih.gov
Endometrial carcinoma (EC) is the second most common gynaecologic cancer worldwide,
when both developed and develo** countries are considered (Sung et al., 2021). In …
when both developed and develo** countries are considered (Sung et al., 2021). In …
[PDF][PDF] Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer
Q ZENG, E Rouleau, M de Bruyn, JF Grau Bejar… - 2024 - scientiasalut.gencat.cat
Background Patients with mismatch repair-deficient (MMRd) endometrial cancer (EC) can
derive great benefit from immune checkpoint inhibitors (ICI). However not all responses and …
derive great benefit from immune checkpoint inhibitors (ICI). However not all responses and …
[PDF][PDF] Lynch Syndrome and Gynecologic Tumors: Incidence, Prophylaxis, and Management of Patients with Cancer. Cancers 2023, 15, 1400
I Capasso, A Santoro, E Lucci Cordisco, E Perrone… - 2023 - academia.edu
This review provides a comprehensive update on recent evidence regarding gynecologic
tumors associated with Lynch Syndrome (LS). Endometrial cancer (EC) and ovarian cancer …
tumors associated with Lynch Syndrome (LS). Endometrial cancer (EC) and ovarian cancer …