Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

Persistent infection or chronic inflammation contributes significantly to tumourigenesis and
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …

Despite great progress has been made in treatment strategies, colorectal cancer (CRC)
remains the predominant life-threatening malignancy with the feature of high morbidity and …

Colorectal cancer (CRC) is a usual digestive tract malignancy and the third main cause of
cancer death around the world, with a high occurrence rate and mortality rate. Conventional …

CXCL8 (also known as IL‐8) can produce different biological effects by binding to its
receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 …

Chemotherapy is the preferred treatment for advanced ovarian cancer, but the 5-year
survival rate remains low partly because of the development of drug resistance. Although it …

Mounting experimental evidence from in vitro and in vivo animal studies points to an
essential role of the CXCL8-CXCR1/2 axis in neutrophils in the pathophysiology of …