In image-based profiling, software extracts thousands of morphological features of cells from
multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used …

Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …

Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient
and powerful way of studying cell biology, and requires computational methods for …

The identification of genetic and chemical perturbations with similar impacts on cell
morphology can elucidate compounds' mechanisms of action or novel regulators of genetic …

Cells can be perturbed by various chemical and genetic treatments and the impact on gene
expression and morphology can be measured via transcriptomic profiling and image-based …

Abstract 'Cell Painting'is an imaging-based high-throughput phenotypic profiling (HTPP)
method in which cultured cells are fluorescently labeled to visualize subcellular structures …

Abstract/outline The field of high content imaging has steadily evolved and expanded
substantially across many industry and academic research institutions since it was first …

Only around 20% of the human proteome is considered to be druggable with small-molecule
antagonists. This leaves some of the most compelling therapeutic targets outside the reach …

Pooled CRISPR screening has emerged as a powerful method of map** gene functions
thanks to its scalability, affordability, and robustness against well or plate-specific …

Gene expression and cell morphology data are high-dimensional biological readouts of
much recent interest for drug discovery. They are able to describe biological systems in …