Metabolomics offers a revolutionary framework for phenoty** individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Capillary electrophoresis‐mass spectrometry (CE‐MS) is now a mature analytical technique
in metabolomics, notably for the efficient profiling of polar and charged metabolites. Over the …

Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …

Background Recently, rapid advances have been made in metabolomics-based, easy-to-
use early cancer detection methods using blood samples. Among metabolites, profiling of …

Cepharanthine (CEP), a natural compound extracted from Stephania cepharantha Hayata,
has been found to have the potential to treat a variety of tumors in recent years. This study …

Highlights•CE–MS is an attractive analytical tool for analyzing the polar ionogenic
metabolome.•A novel sheathless interface for CE–MS allows highly sensitive metabolic …

Every 5 years or so new technologies, or new combinations of old ones, seemingly burst
onto the science scene and are then sought after until they reach the point of becoming …

A major constraint in large-scale mass spectrometry (MS)-based metabolomic initiatives is
the low sample throughput associated with chromatographic or electrophoretic separations …

CE‐MS has emerged as a powerful technique for the profiling of (highly) polar and charged
metabolites in biological samples. This review provides an update of the most recent …

A molecular description of the mechanisms by which aging is produced is still very limited.
Here, we have determined the plasma metabolite profile by using high-throughput …