Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway
Y Jiang, J Zhou, P Luo, H Gao, Y Ma, YS Chen, L Li… - …, 2018 - thelancet.com
Background As a neurotrophic factor, prosaposin (PSAP) can exert neuroprotective and
neurotrophic effects. It is involved in the occurrence and development of prostate and breast …
neurotrophic effects. It is involved in the occurrence and development of prostate and breast …
[HTML][HTML] Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms
L Yan, Z Wen, Y Yang, A Liu, F Li, Y Zhang… - Biomedicine & …, 2024 - Elsevier
As a dual-function protein, prosaposin (PSAP) is a lysosome-associated protein that
participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate …
participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate …
[HTML][HTML] HtrA1: Its future potential as a novel biomarker for cancer
E Altobelli, D Marzioni, A Lattanzi… - Oncology …, 2015 - spandidos-publications.com
HtrA1 appears to be involved in several physiological processes as well as in the
pathogenesis of conditions such as Alzheimer's disease and osteoarthritis. It has also been …
pathogenesis of conditions such as Alzheimer's disease and osteoarthritis. It has also been …
Prosaposin is a biomarker of mesenchymal glioblastoma and regulates mesenchymal transition through the TGF‐β1/Smad signaling pathway
Y Jiang, J Zhou, D Hou, P Luo, H Gao… - The Journal of …, 2019 - Wiley Online Library
Mesenchymal glioblastoma (GBM) is the most aggressive subtype of GBM. Our previous
study found that neurotrophic factor prosaposin (PSAP) is highly expressed and secreted in …
study found that neurotrophic factor prosaposin (PSAP) is highly expressed and secreted in …
Putative biomarkers for malignant pleural mesothelioma suggested by proteomic analysis of cell secretome
S Lacerenza, F Ciregia, L Giusti… - Cancer genomics & …, 2020 - cgp.iiarjournals.org
Background: Malignant pleural mesothelioma (MPM) a rare neoplasm linked to asbestos
exposure is characterized by a poor prognosis. Soluble mesothelin is currently considered …
exposure is characterized by a poor prognosis. Soluble mesothelin is currently considered …
Global methylation profiling to identify epigenetic signature of gallbladder cancer and gallstone disease
Promoter methylation in various tumor suppressor genes is reported to influence gallbladder
carcinogenesis. Here, we aimed to identify methylation status in gallbladder cancer (GBC) …
carcinogenesis. Here, we aimed to identify methylation status in gallbladder cancer (GBC) …
Macrophage migration inhibitory factor-a therapeutic target in gallbladder cancer
Background Poor prognosis in gallbladder cancer is due to late presentation of the disease,
lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early …
lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early …
Quantitative tissue proteome profile reveals neutrophil degranulation and remodeling of extracellular matrix proteins in early stage gallbladder cancer
Gallbladder cancer (GBC) is an aggressive malignancy of the gastrointestinal tract with a
poor prognosis. It is important to understand the molecular processes associated with the …
poor prognosis. It is important to understand the molecular processes associated with the …
Increased expression of tissue/salivary transgelin mrna predicts poor prognosis in patients with oral squamous cell carcinoma (OSCC) surgery
J Bu, X Bu, B Liu, F Chen… - Medical Science Monitor …, 2015 - pmc.ncbi.nlm.nih.gov
Background Transgelin is supposed to be a tumor suppression gene and it is down-
regulated in a variety of human cancers. However, the role of transgelin in different cancers …
regulated in a variety of human cancers. However, the role of transgelin in different cancers …
Circular RNA circVAPA promotes cell proliferation in hepatocellular carcinoma
C Liu, X Zhong, J Li, F Xu - Human Gene Therapy Clinical …, 2019 - liebertpub.com
Hepatocellular carcinoma (HCC) is the most common malignancy in liver and is one of the
leading causes of cancer-induced deaths all over the world. Circular RNAs (circRNAs) have …
leading causes of cancer-induced deaths all over the world. Circular RNAs (circRNAs) have …