Drug-induced liver injury

RJ Andrade, N Chalasani, ES Björnsson… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Burden of liver diseases in the world

SK Asrani, H Devarbhavi, J Eaton, PS Kamath - Journal of hepatology, 2019 - Elsevier
Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due
to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular …

Astaxanthin activated the Nrf2/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury

X Cai, S Hua, J Deng, Z Du, D Zhang… - … applied materials & …, 2022 - ACS Publications
Acetaminophen (APAP)-induced liver injury (AILI) is a common liver disease in clinical
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

RJ Fontana, I Liou, A Reuben, A Suzuki, MI Fiel… - Hepatology, 2023 - journals.lww.com
There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice

Y Zeng, R Wu, F Wang, S Li, L Li, Y Li, P Qin, M Wei… - Cell Host & Microbe, 2023 - cell.com
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The
impact of the gut microbiota and associated metabolites on APAP and liver function remains …

Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts

F Saliba, R Bañares, FS Larsen, A Wilmer… - Intensive Care …, 2022 - Springer
The present narrative review on albumin dialysis provides evidence-based and expert
opinion guidelines for clinicians caring for adult patients with different types of liver failure …

Acetaminophen (APAP) hepatotoxicity—isn't it time for APAP to go away?

WM Lee - Journal of hepatology, 2017 - Elsevier
Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever
around the world. At the same time, APAP can cause dose-related hepatocellular necrosis …

Hepatic encephalopathy

EFM Wijdicks - New England Journal of Medicine, 2016 - Mass Medical Soc
Hepatic Encephalopathy | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Management of acute liver failure: update 2022

S Tujios, RT Stravitz, WM Lee - Seminars in liver disease, 2022 - thieme-connect.com
Abbreviated pathogenesis and clinical course of the acute liver failure syndrome. The
pathogenesis and clinical course of the syndrome of acute liver failure (ALF) differs …