Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

We define a new concept of 'active milieu'that unifies all components of nervous tissue
(neuronal and glial compartments, extracellular space, extracellular matrix, and vasculature) …

Genetic perturbations of cortical development can lead to neurodevelopmental disease,
including autism spectrum disorder (ASD). To identify genomic regions crucial to …

Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular
zone and outer subventricular zone. Although outer subventricular zone radial glia may …

Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of
skeletal muscle as a consequence of motor neuron degeneration. Interactions between …

Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

The brain, endocrine, and immune systems are inextricably linked. Immune molecules have
a powerful impact on neuroendocrine function, including hormone–behavior interactions …

Animal tissues are made up of multiple cell types that are increasingly well-characterized,
yet our understanding of the core principles that govern tissue organization is still …