Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

During the past 85 years of antibiotic use, we have learned a great deal about how these
'miracle'drugs work. We know the molecular structures and interactions of these drugs and …

Rho is a ring-shaped hexameric ATP-dependent molecular motor. Together with the
transcription elongation factor NusG, Rho mediates factor-dependent transcription …

Structural biology studies performed inside cells can capture molecular machines in action
within their native context. In this work, we developed an integrative in-cell structural …

Bacteria adapt to environmental stimuli by adjusting their transcriptomes in a complex
manner, the full potential of which has yet to be established for any individual bacterial …

Transcript termination is essential for accurate gene expression and the removal of RNA
polymerase (RNAP) at the ends of transcription units. In bacteria, two mechanisms are …

Tight coupling of transcription and translation is considered a defining feature of bacterial
gene expression,. The pioneering ribosome can both physically associate and kinetically …

Molecular genetic research on bacteriophage lambda carried out during its golden age from
the mid-1950s to mid-1980s was critically important in the attainment of our current …

Protein synthesis by ribosomes takes place on a linear substrate but at non-uniform speeds.
Transient pausing of ribosomes can affect a variety of co-translational processes, including …

In bacteria, transcription and translation are coupled processes in which the movement of
RNA polymerase (RNAP)–synthesizing messenger RNA (mRNA) is coordinated with the …