Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Organizational principles of 3D genome architecture
Studies of 3D chromatin organization have suggested that chromosomes are hierarchically
organized into large compartments composed of smaller domains called topologically …
organized into large compartments composed of smaller domains called topologically …
Transcription shapes 3D chromatin organization by interacting with loop extrusion
EJ Banigan, W Tang… - Proceedings of the …, 2023 - National Acad Sciences
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation
In most bacteria, chromosome segregation is driven by the ParAB S system where the
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …
3D chromatin architecture and transcription regulation in cancer
Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding
Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …
chromosome spatial organization. It is unclear, however, how they perform relative to each …
Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
The spatial organization of chromosomes has key functional roles, yet how chromosomes
fold remains poorly understood at the single-molecule level. Here, we employ models of …
fold remains poorly understood at the single-molecule level. Here, we employ models of …
Chromosome organization by one-sided and two-sided loop extrusion
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …
CTCF mediates dosage-and sequence-context-dependent transcriptional insulation by forming local chromatin domains
Insulators play a critical role in spatiotemporal gene regulation in animals. The evolutionarily
conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but …
conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but …
Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations
PR Cook, D Marenduzzo - Nucleic acids research, 2018 - academic.oup.com
Current models for the folding of the human genome see a hierarchy stretching down from
chromosome territories, through A/B compartments and topologically-associating domains …
chromosome territories, through A/B compartments and topologically-associating domains …